Globesity epidemic, insulin resistance, type II diabetes and syndrome X is frequently associated with fatty liver, alterations that can be benign and not progressive, or lead to cryptogenic cirrhosis, hepatoma and liver failure, because it is of chronic injury of this important body. Fatty infiltration of the liver is associated with a variety of conditions and diseases. Fatty liver or steatosis is a metabolic disease, which when associated with inflammation is called steatohepatitis, a condition which, as we said, can lead to cryptogenic cirrhosis.

We speak here of a non-alcoholic pathological changes (as the toxic of course produce steatohepatitis), which is very common and usually is diagnosed incidentally during abdominal ultrasound scans (liver hyperechoic) made to the assessment of patients. Fatty infiltration of the liver usually will not cause any clinical symptomatology. Normally the liver is 5% of fat, almost half made up of phospholipids, to a lesser extent triglycerides and cholesterol is unesterified. But it exceeds that liver fat content, mainly at the expense of triglyceride-spoken of fatty liver. It is associated with obesity, diabetes and hyperlipidemia, insulin resistance and syndrome X, with rapid weight loss diets, or the swing of it.

Although there may be signs of right upper quadrant dull pain, many patients turn to have an unexplained and persistent elevation of liver tests, AST, ALT and alkaline phosphatase (demonstration and of steatohepatitis, as in the simple steatosis, liver function tests are normal) , 70% are overweight and can detect some degree of hepatomegaly. Steatosis alone is a non-progressive disease, but it is when there is inflammation. The diagnosis is based on elevated transaminase levels, no significant alcohol consumption (<40 g / week), negative blood test for hepatitis B and C, and can be easily detected by liver ultrasound to get accuracy of ultrasonography in diagnosing fatty liver, but a definitive diagnosis is by biopsy liver.

Obesity is thought to be the most common cause of fatty infiltration of the liver. There are treatment strategies that can improve the picture, such as avoiding alcohol consumption and intake of hepatotoxic as acetaminophen, anti-inflammatory drugs, estrogen, and the gradual reduction in weight (low-fat diet versus low-carb) to avoid the rapid loss because the picture gets worse . We recommend the vaccination against hepatitis A and B, and drugs that prevent oxidative stress such as vitamin E, and (remember the hepatoprotective, In Barranquilla on famous Necroton), Silymarin, lecithin, betaine, or selenium; drugs that improve insulin sensitivity such as rosiglitazone or metformiu. In fatty infiltration of the liver, there is an increased amount of fat in the normal cells so you have to treat associated diseases such as diabetes or hyperlipidemia. It has also been used ursodeoxycholic acid and gemfibrozil. However, the use of many of these drugs do not have a good backup of evidence-based medicine.

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